Chemistry Capabilities
Exelgen Discovery labs are amongst the best equipped in the industry to efficiently service collaborations, contract research and custom synthesis projects; equipment includes:
High-Throughput Parallel SynthesisExelgen Discovery's high-throughput chemistry operations are supported by:
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Scale Equipment Exelgen Discovery has excellent scale-up equipment, including:
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Separation & DryingDedicated Genevac equipment including HT12, HT24, MegaVac and EZ2+ which can handle plates, vials and round bottom flasks thus allowing concentration of up to 500ml. |
High-Pressure ChemistryHigh-pressure reactions are usually undertaken in either a 2 Litre or 1 gallon T316 Stainless steel vessel; working pressure 600psi; max pressure 1500psi. Other high-pressure equipment includes 2 x 25ml, 2 x 50ml and 1 x 600ml stainless steel vessel [1500psi]. |
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Analytical Instrumentation
Research AnalysisThe analysis team supporting the R&D chemistry operations has access to a variety of techniques using NMR on the Bruker Avance 400 MHz, or LC/MS operating on the Waters platform (both analytical and preparative systems). |
High-Throughput AnalysisLibrary specific LC/MS assays are performed on Waters LC/MS instruments, operating Alliance 2795 LC modules, coupled with a 2996 photodiode array detector, and a ZQ2000 mass spectrometer. We additionally have a 4-channel MUX enabled ZQ, with 4x 1525micro binary LC pumps, a 2777 Sample Manager and a 2488 UV detector. |
High-Throughput Parallel Purification Exelgen Discovery operates 4 Waters LC-MS systems running FractionLynx with unattended operation functionality. |
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Library Design Tools
A broad suite of state-of-the-art design tools are utilised to service projects covering the following key areas:
Compound Collection Analysis and Enhancement
Metric Computations
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Library Design
Virtual Libraries designed in conjunction with medicinal chemists
Optimized for lead-like or drug-like properties Optimized for diversity or specific target
Multi-objective library design using:
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Lead Generation
Idea generation tools Structure based virtual screening
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